CAS No.: 1869912-39-9
(R)-4-(2-(4-(1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one Catalog No. CSN19702
AZD5153 exhibits excellent pharmacokinetic profile and high potency in vitro and in vivo effecting c-Myc downregulation and tumor growth inhibition in xenograft studies.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn
纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03205176 Malignant Solid Tumors ... more >> Lymphoma Ovarian Cancer Collapse << Phase 1 Recruiting July 26, 2019 United States, Florida ... more >> Research Site Recruiting Sarasota, Florida, United States, 34232 United States, Oklahoma Research Site Recruiting Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee Research Site Recruiting Nashville, Tennessee, United States, 37203 Collapse << - 参考文献
- [1] Rhyasen GW, Hattersley MM, et al. AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.
- [2] Bradbury RH, Callis R, et al. Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4] triazolo[4,3-b] pyridazin-6-yl)-4-piperidyl] phenoxy] ethyl] -1,3-dimethyl-piperazin-2-one (AZD5153). J Med Chem. 2016 Sep 8;59(17):7801-17.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1869912-39-9 | 储存条件 |
|
|
| 分子式 | C25H33N7O3 | 运输 | 蓝冰 | |
| 分子量 | 479.57 | 别名 |
